What is Cialis mechanism of action?

The drug's active ingredient, tadalafil promotes the inhibition of production of the enzyme phosphodiesterase type 5 (PDE5), which main task is to regulate the concentration of cyclic guanosine monophosphate (cGMP) in the smooth muscles of the cavernous body of penis. With the effect of tadalafil, there occurs an increase in the level of cGMP to a natural limit. This fact contributes to a healthy erection in response to sexual stimulation. After completion of sexual intercourse, penis returns to its natural relaxed state. The drug's maximum concentration in blood is achieved approximately 2 hours after administration. Some men experience fear of a possible decrease in sex drive after the end of treatment. Though, clinical trials completely deny such unsubstantiated "facts." Alternatively, those men that passed therapy with Cialis reported a significant increase in erection after the termination of treatment.

How to use Cialis? What is the dosage? One 20 mg tablet is taken at least 30 minutes prior to sexual intercourse, washed down with water. Drug activity is maintained for 36 hours. The maximum daily dose of tadalafil is 40 mg; recommended dose - 20 mg (one tablet).

Does Cialis cause any side effects? Like any other medication, Cialis may cause side effects. However, clinical studies showed: only about 5% of patients on Cialis felt weak headaches; 3% - back pain, facial flushing, and nasal congestion. Side effects feature short-term and ill-defined character. With chronic administration (more than 7 consecutive days), side effects disappeared completely.

Are there any contraindications to the use of Cialis? Before taking Cialis, as well as other medication, always consult a physician. The use of Cialis is strictly prohibited, if you have: hypersensitivity to the drug, angina pectoris, myocardial infarction in past (less than 3 months ago), heart failure (chronic or evolved), vascular hypotension (blood pressure is consistently below 90/50 mm Hg), a stroke in past (over a period of six months), severe renal dysfunction, chronic renal failure, predisposition to priapism, serious deformity of penis (congenital or acquired).

Does Cialis interact with other drugs? Such medications as ritonavir, ketoconazole, and presumably, itraconazole, erythromycin and saquinavir increase the level of tadalafil concentration in blood. Being an inducer of CYP3A4, rifampicin causes a decrease in the pharmacological effect of Cialis. Simultaneous administration of the drug along with nitric oxide donators and nitrates in their various forms can cause serious harm to health. Prior to the administration of Cialis, cessation of treatment with the mentioned medicines is highly recommended.

How efficient and safe is Cialis? Clinical trials show: 90% of Cialis subjects in different age categories felt significant improvement in erectile function. The drug features excellent tolerability. Tadalafil is absolutely safe to use, while causing no addiction or decrease in erectile function after the end of treatment. With Cialis, men easily overcome both physiological and psychological problems, such as "failure expectation syndrome," which is a precursor of much more serious problems. Taking just one pill, you enjoy sex with a partner and truly believe in yourself.

Why the price for generics is much lower? Generics are analogues of known drugs with efficiency and composition identical to those of original. Low cost for generic Cialis is due to the fact that pharmaceutical factories spend money only on the drug's production (not development). As a rule, this way they save a few billion dollars. Therefore, generic versions are much cheaper.

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